Publications

2021



Mechanisms of quality control differ in male and female germ cells: Candi E, Melino G, Tóth A, Dötsch V.; Cell Death Differ. 2021 Jul;28(7):2300-2302. doi: 10.1038/s41418-021-00818-8. Epub 2021 Jun 15.

Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice.: Dereli I, Stanzione M, Olmeda F, Papanikos F, Baumann M, Demir S, Carofiglio F, Lange J, de Massy B, Baarends WM, Turner J, Rulands S, Tóth A.; Nucleic Acids Res. 2021 Mar 18;49(5):2609-2628. doi: 10.1093/nar/gkab082.

2020

Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.: Bondarieva A, Raveendran K, Telychko V, Rao PHBD, Ravindranathan R, Zorzompokou C, Finsterbusch F, Dereli I, Papanikos F, Tränkner D, Schleiffer A, Fei JF, Klimova A, Ito M, Dhananjaya S., Kulkarni DS, Roeder I, Hunter N, Tóth A.; Nature Communications 2020 Jun 18; 11:3101; doi:10.1038/s41467-020-16885-3

2019

Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes.: Papanikos F, Clément JAJ, Testa E, Ravindranathan R, Grey C, Dereli I, Bondarieva A, Valerio-Cabrera S, Stanzione M, Schleiffer A, Jansa P, Lustyk D, Fei JF, Adams IR, Forejt J, Barchi M, de Massy B, Tóth A.; Mol Cell. 2019 Jun 6;74(5):1069-1085.e11. doi: 10.1016/j.molcel.2019.03.022. Epub 2019 Apr 15.

2018

ATR is a multifunctional regulator of male mouse meiosis.: Widger A, Mahadevaiah SK, Lange J, ElInati E, Zohren J, Hirota T, Pacheco S, Maldonado-Linares A, Stanzione M, Ojarikre O, Maciulyte V, de Rooij DG, Tóth A, Roig I, Keeney S, Turner JMA.; Nat Commun. 2018 Jul 5;9(1):2621. doi: 10.1038/s41467-018-04850-0.

Repair of exogenous DNA double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse meiocytes, and is altered in the absence of HORMAD1.: Carofiglio F, Sleddens-Linkels E, Wassenaar E, Inagaki A, van Cappellen WA, Grootegoed JA, Toth A., Baarends WM.; DNA Repair (Amst.) 2017 2018 Mar;63:25-38. doi: 10.1016/j.dnarep.2018.01.007. Epub 2018 Jan 31.

2017

The PRDM9 KRAB domain is required for meiosis and involved in protein interactions.: Imai Y, Baudat F, Taillepierre M, Stanzione M, Toth A., de Massy B.; Chromosoma 2017 Dec;126(6):681-695. doi: 10.1007/s00412-017-0631-z. Epub 2017 May 19.

The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.: Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A., Cleveland DW, Corbett KD.; EMBO J. 2017 Aug 15;36(16):2419-2434. doi: 10.15252/embj.201797291. Epub 2017 Jun 28.

How Meiosis Creates the Single-Copy Genome.: Herbert M, Toth A.; Dev Cell. 2017 Jan 9;40(1):3-4. doi: 10.1016/j.devcel.2016.12.019.

Protein and Chromosome Analysis in Mammalian Meiocytes.: Stevense M, Jessberger R, Tóth A.; Methods Mol Biol. 2017;1515:97-111.

2016

Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.: Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A.; Nat Cell Biol. 2016 Nov;18(11):1208-1220. doi: 10.1038/ncb3417. Epub 2016 Oct 10.

C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility.: Gómez-H L, Felipe-Medina N, Sánchez-Martín M, Davies OR, Ramos I, García-Tuñón I, de Rooij DG, Dereli I, Tóth A, Barbero JL, Benavente R, Llano E, Pendas AM.; Nat Commun. 2016 Oct 31;7:13298. doi: 10.1038/ncomms13298.

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein.: Finsterbusch F, Ravindranathan R, Dereli I, Stanzione M, Tränkner D, Tóth A.; PLoS Genet. 2016 Oct 19;12(10):e1006393. doi: 10.1371/journal.pgen.1006393. eCollection 2016 Oct.

Mammalian meiotic silencing exhibits sexually dimorphic features.: Cloutier JM, Mahadevaiah SK, ElInati E, Tóth A, Turner J.; Chromosoma. 2016 Jun;125(2):215-26. doi: 10.1007/s00412-015-0568-z. Epub 2015 Dec 28.

The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice.: Papanikos F, Daniel K, Goercharn-Ramlal A, Fei JF, Kurth T, Wojtasz L, Dereli I, Fu J, Penninger J, Habermann B, Surani A, Stewart AF, Toth A.; Chromosoma. 2016 May 10. [Epub ahead of print]

Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability.: Toth A, Jessberger R.; Curr Biol. 2016 Apr 25;26(8):R329-31. doi: 10.1016/j.cub.2016.02.059.

Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.: Abby E, Tourpin S, Ribeiro J, Daniel K, Messiaen S, Moison D, Guerquin J, Gaillard JC, Armengaud J, Langa F, Toth A, Martini E, Livera G.; Nat Commun. 2016 Jan 8;7:10324. doi: 10.1038/ncomms10324.

2015

Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals.: Cloutier JM, Mahadevaiah SK, ElInati E, Nussenzweig A, Tóth A, Turner JM.; PLoS Genet. 2015 Oct 28;11(10):e1005462. doi: 10.1371/journal.pgen.1005462. eCollection 2015 Oct. Erratum in: PLoS Genet. 2015 Dec;11(12):e1005753.

MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.: Kumar R, Ghyselinck N, Ishiguro K, Watanabe Y, Kouznetsova A, Höög C, Strong E, Schimenti J, Daniel K, Toth A, de Massy B.; J Cell Sci. 2015 May 1;128(9):1800-11. doi: 10.1242/jcs.165464. Epub 2015 Mar 20.

Strong artificial selection in domestic mammals did not result in an increased recombination rate.: Muñoz-Fuentes V, Marcet-Ortega M, Alkorta-Aranburu G, Linde Forsberg C, Morrell JM, Manzano-Piedras E, Söderberg A, Daniel K, Villalba A, Toth A, Di Rienzo A, Roig I, Vilà C.; Mol Biol Evol. 2015 Feb;32(2):510-23. doi: 10.1093/molbev/msu322. Epub 2014 Nov 19.

2014

Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.: Daniel K, Tränkner D, Wojtasz L, Shibuya H, Watanabe Y, Alsheimer M, Tóth A.; BMC Cell Biol. 2014 May 22;15:17. doi: 10.1186/1471-2121-15-17.

2013

MEIOB targets single-strand DNA and is necessary for meiotic recombination.: Souquet B, Abby E, Hervé R, Finsterbusch F, Tourpin S, Le Bouffant R, Duquenne C, Messiaen S, Martini E, Bernardino-Sgherri J, Toth A, Habert R, Livera G.; PLoS Genet. 2013;9(9):e1003784. doi: 10.1371/journal.pgen.1003784. Epub 2013 Sep 19

ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing.: Royo H, Prosser H, Ruzankina Y, Mahadevaiah SK, Cloutier JM, Baumann M, Fukuda T, Höög C, Tóth A, de Rooij DG, Bradley A, Brown EJ, Turner JM.; Genes Dev. 2013 Jul 1;27(13):1484-94. doi: 10.1101/gad.219477.113.

2012

Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms.: Wojtasz L, Cloutier JM, Baumann M, Daniel K, Varga J, Fu J, Anastassiadis K, Stewart AF, Reményi A, Turner JM, Tóth A.; Genes Dev. 2012 May 1;26(9):958-73. doi: 10.1101/gad.187559.112.

2011

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.: Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Tóth A.; Nat Cell Biol. 2011 May;13(5):599-610. doi: 10.1038/ncb2213. Epub 2011 Apr 10.

2010

Male meiosis: Y keep it silenced?: Tóth A, Jessberger R.; Curr Biol. 2010 Dec 7;20(23):R1022-4. doi: 10.1016/j.cub.2010.11.002.

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.: Pulvers JN, Bryk J, Fish JL, Wilsch-Bräuninger M, Arai Y, Schreier D, Naumann R, Helppi J, Habermann B, Vogt J, Nitsch R, Tóth A, Enard W, Pääbo S, Huttner WB.; Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16595-600. doi: 10.1073/pnas.1010494107. Epub 2010 Sep 7.

Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis.: Roig I, Dowdle JA, Toth A, de Rooij DG, Jasin M, Keeney S.; PLoS Genet. 2010 Aug 12;6(8). pii: e1001062. doi: 10.1371/journal.pgen.1001062.

A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes.: Fukuda T, Daniel K, Wojtasz L, Toth A, Höög C.; Exp Cell Res. 2010 Jan 15;316(2):158-71. doi: 10.1016/j.yexcr.2009.08.007. Epub 2009 Aug 15.

2009

Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.: Wojtasz L*, Daniel K*, Roig I, Bolcun-Filas E, Xu H, Boonsanay V, Eckmann CR, Cooke HJ, Jasin M, Keeney S, McKay MJ, Toth A.; PLoS Genet. 2009 Oct;5(10):e1000702. doi: 10.1371/journal.pgen.1000702. Epub 2009 Oct 23.; *This Authors contributed equally to this work

Fluorescence activated cell sorting of live female germ cells and somatic cells of the mouse fetal gonad based on forward and side scattering.: Wojtasz L, Daniel K, Toth A.; Cytometry A. 2009 Jun;75(6):547-53. doi: 10.1002/cyto.a.20729.

on the way to PIship

Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.: Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Tóth A, Nasmyth K.; Dev Cell. 2003 May;4(5):727-39.

A screen for genes required for meiosis and spore formation based on whole-genome expression.: Rabitsch KP*, Tóth A*, Gálová M, Schleiffer A, Schaffner G, Aigner E, Rupp C, Penkner AM, Moreno-Borchart AC, Primig M, Esposito RE, Klein F, Knop M, Nasmyth K.; Curr Biol. 2001 Jul 10;11(13):1001-9.*This Authors contributed equally to this work.

Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i.: Tóth A*, Rabitsch KP*, Gálová M, Schleiffer A, Buonomo SB, Nasmyth K.; Cell. 2000 Dec 22;103(7):1155-68.*This Authors contributed equally to this work.

Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins.: Ciosk R, Shirayama M, Shevchenko A, Tanaka T, Toth A, Shevchenko A, Nasmyth K.; Mol Cell. 2000 Feb;5(2):243-54.

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.: Shirayama M, Tóth A, Gálová M, Nasmyth K.; Nature. 1999 Nov 11;402(6758):203-7.

Finishing the cell cycle.: Novák B, Tóth A, Csikász-Nagy A, Györffy B, Tyson JJ, Nasmyth K.; J Theor Biol. 1999 Jul 21;199(2):223-33.

Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.: Tóth A, Ciosk R, Uhlmann F, Galova M, Schleiffer A, Nasmyth K.; Genes Dev. 1999 Feb 1;13(3):320-33.