Publications

2018

ATR is a multifunctional regulator of male mouse meiosis.: Widger A, Mahadevaiah SK, Lange J, ElInati E, Zohren J, Hirota T, Pacheco S, Maldonado-Linares A, Stanzione M, Ojarikre O, Maciulyte V, de Rooij DG, Tóth A, Roig I, Keeney S, Turner JMA.; Nat Commun. 2018 Jul 5;9(1):2621. doi: 10.1038/s41467-018-04850-0.

Repair of exogenous DNA double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse meiocytes, and is altered in the absence of HORMAD1.: Carofiglio F, Sleddens-Linkels E, Wassenaar E, Inagaki A, van Cappellen WA, Grootegoed JA, Toth A., Baarends WM.; DNA Repair (Amst.) 2017 2018 Mar;63:25-38. doi: 10.1016/j.dnarep.2018.01.007. Epub 2018 Jan 31.

2017

The PRDM9 KRAB domain is required for meiosis and involved in protein interactions.: Imai Y, Baudat F, Taillepierre M, Stanzione M, Toth A., de Massy B.; Chromosoma 2017 Dec;126(6):681-695. doi: 10.1007/s00412-017-0631-z. Epub 2017 May 19.

The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.: Ye Q, Kim DH, Dereli I, Rosenberg SC, Hagemann G, Herzog F, Tóth A., Cleveland DW, Corbett KD.; EMBO J. 2017 Aug 15;36(16):2419-2434. doi: 10.15252/embj.201797291. Epub 2017 Jun 28.

How Meiosis Creates the Single-Copy Genome.: Herbert M, Toth A.; Dev Cell. 2017 Jan 9;40(1):3-4. doi: 10.1016/j.devcel.2016.12.019.

Protein and Chromosome Analysis in Mammalian Meiocytes.: Stevense M, Jessberger R, Tóth A.; Methods Mol Biol. 2017;1515:97-111.

2016

Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.: Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A.; Nat Cell Biol. 2016 Nov;18(11):1208-1220. doi: 10.1038/ncb3417. Epub 2016 Oct 10.

C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility.: Gómez-H L, Felipe-Medina N, Sánchez-Martín M, Davies OR, Ramos I, García-Tuñón I, de Rooij DG, Dereli I, Tóth A, Barbero JL, Benavente R, Llano E, Pendas AM.; Nat Commun. 2016 Oct 31;7:13298. doi: 10.1038/ncomms13298.

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein.: Finsterbusch F, Ravindranathan R, Dereli I, Stanzione M, Tränkner D, Tóth A.; PLoS Genet. 2016 Oct 19;12(10):e1006393. doi: 10.1371/journal.pgen.1006393. eCollection 2016 Oct.

Mammalian meiotic silencing exhibits sexually dimorphic features.: Cloutier JM, Mahadevaiah SK, ElInati E, Tóth A, Turner J.; Chromosoma. 2016 Jun;125(2):215-26. doi: 10.1007/s00412-015-0568-z. Epub 2015 Dec 28.

The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice.: Papanikos F, Daniel K, Goercharn-Ramlal A, Fei JF, Kurth T, Wojtasz L, Dereli I, Fu J, Penninger J, Habermann B, Surani A, Stewart AF, Toth A.; Chromosoma. 2016 May 10. [Epub ahead of print]

Oogenesis: Ageing Oocyte Chromosomes Rely on Amazing Protein Stability.: Toth A, Jessberger R.; Curr Biol. 2016 Apr 25;26(8):R329-31. doi: 10.1016/j.cub.2016.02.059.

Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.: Abby E, Tourpin S, Ribeiro J, Daniel K, Messiaen S, Moison D, Guerquin J, Gaillard JC, Armengaud J, Langa F, Toth A, Martini E, Livera G.; Nat Commun. 2016 Jan 8;7:10324. doi: 10.1038/ncomms10324.

2015

Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals.: Cloutier JM, Mahadevaiah SK, ElInati E, Nussenzweig A, Tóth A, Turner JM.; PLoS Genet. 2015 Oct 28;11(10):e1005462. doi: 10.1371/journal.pgen.1005462. eCollection 2015 Oct. Erratum in: PLoS Genet. 2015 Dec;11(12):e1005753.

MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.: Kumar R, Ghyselinck N, Ishiguro K, Watanabe Y, Kouznetsova A, Höög C, Strong E, Schimenti J, Daniel K, Toth A, de Massy B.; J Cell Sci. 2015 May 1;128(9):1800-11. doi: 10.1242/jcs.165464. Epub 2015 Mar 20.

Strong artificial selection in domestic mammals did not result in an increased recombination rate.: Muñoz-Fuentes V, Marcet-Ortega M, Alkorta-Aranburu G, Linde Forsberg C, Morrell JM, Manzano-Piedras E, Söderberg A, Daniel K, Villalba A, Toth A, Di Rienzo A, Roig I, Vilà C.; Mol Biol Evol. 2015 Feb;32(2):510-23. doi: 10.1093/molbev/msu322. Epub 2014 Nov 19.

2014

Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.: Daniel K, Tränkner D, Wojtasz L, Shibuya H, Watanabe Y, Alsheimer M, Tóth A.; BMC Cell Biol. 2014 May 22;15:17. doi: 10.1186/1471-2121-15-17.

2013

MEIOB targets single-strand DNA and is necessary for meiotic recombination.: Souquet B, Abby E, Hervé R, Finsterbusch F, Tourpin S, Le Bouffant R, Duquenne C, Messiaen S, Martini E, Bernardino-Sgherri J, Toth A, Habert R, Livera G.; PLoS Genet. 2013;9(9):e1003784. doi: 10.1371/journal.pgen.1003784. Epub 2013 Sep 19

ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing.: Royo H, Prosser H, Ruzankina Y, Mahadevaiah SK, Cloutier JM, Baumann M, Fukuda T, Höög C, Tóth A, de Rooij DG, Bradley A, Brown EJ, Turner JM.; Genes Dev. 2013 Jul 1;27(13):1484-94. doi: 10.1101/gad.219477.113.

2012

Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms.: Wojtasz L, Cloutier JM, Baumann M, Daniel K, Varga J, Fu J, Anastassiadis K, Stewart AF, Reményi A, Turner JM, Tóth A.; Genes Dev. 2012 May 1;26(9):958-73. doi: 10.1101/gad.187559.112.

2011

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.: Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Tóth A.; Nat Cell Biol. 2011 May;13(5):599-610. doi: 10.1038/ncb2213. Epub 2011 Apr 10.

2010

Male meiosis: Y keep it silenced?: Tóth A, Jessberger R.; Curr Biol. 2010 Dec 7;20(23):R1022-4. doi: 10.1016/j.cub.2010.11.002.

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.: Pulvers JN, Bryk J, Fish JL, Wilsch-Bräuninger M, Arai Y, Schreier D, Naumann R, Helppi J, Habermann B, Vogt J, Nitsch R, Tóth A, Enard W, Pääbo S, Huttner WB.; Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16595-600. doi: 10.1073/pnas.1010494107. Epub 2010 Sep 7.

Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis.: Roig I, Dowdle JA, Toth A, de Rooij DG, Jasin M, Keeney S.; PLoS Genet. 2010 Aug 12;6(8). pii: e1001062. doi: 10.1371/journal.pgen.1001062.

A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes.: Fukuda T, Daniel K, Wojtasz L, Toth A, Höög C.; Exp Cell Res. 2010 Jan 15;316(2):158-71. doi: 10.1016/j.yexcr.2009.08.007. Epub 2009 Aug 15.

2009

Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.: Wojtasz L*, Daniel K*, Roig I, Bolcun-Filas E, Xu H, Boonsanay V, Eckmann CR, Cooke HJ, Jasin M, Keeney S, McKay MJ, Toth A.; PLoS Genet. 2009 Oct;5(10):e1000702. doi: 10.1371/journal.pgen.1000702. Epub 2009 Oct 23.; *This Authors contributed equally to this work

Fluorescence activated cell sorting of live female germ cells and somatic cells of the mouse fetal gonad based on forward and side scattering.: Wojtasz L, Daniel K, Toth A.; Cytometry A. 2009 Jun;75(6):547-53. doi: 10.1002/cyto.a.20729.

on the way to PIship

Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.: Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Tóth A, Nasmyth K.; Dev Cell. 2003 May;4(5):727-39.

A screen for genes required for meiosis and spore formation based on whole-genome expression.: Rabitsch KP*, Tóth A*, Gálová M, Schleiffer A, Schaffner G, Aigner E, Rupp C, Penkner AM, Moreno-Borchart AC, Primig M, Esposito RE, Klein F, Knop M, Nasmyth K.; Curr Biol. 2001 Jul 10;11(13):1001-9.*This Authors contributed equally to this work.

Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i.: Tóth A*, Rabitsch KP*, Gálová M, Schleiffer A, Buonomo SB, Nasmyth K.; Cell. 2000 Dec 22;103(7):1155-68.*This Authors contributed equally to this work.

Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins.: Ciosk R, Shirayama M, Shevchenko A, Tanaka T, Toth A, Shevchenko A, Nasmyth K.; Mol Cell. 2000 Feb;5(2):243-54.

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.: Shirayama M, Tóth A, Gálová M, Nasmyth K.; Nature. 1999 Nov 11;402(6758):203-7.

Finishing the cell cycle.: Novák B, Tóth A, Csikász-Nagy A, Györffy B, Tyson JJ, Nasmyth K.; J Theor Biol. 1999 Jul 21;199(2):223-33.

Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.: Tóth A, Ciosk R, Uhlmann F, Galova M, Schleiffer A, Nasmyth K.; Genes Dev. 1999 Feb 1;13(3):320-33.

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